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Prevalence of Hepatitis B Viral Infection in Punjab Province of Pakistan

Prevalence of Hepatitis B Viral Infection in Punjab Province of Pakistan

Nasar Khan1,2, Fahad Ali3,7, Sulaiman Bahadar5,*, Khalil ur Rahman3, Abdul Aziz3, Noor ul Akbar4, Muhammad Daud6, Azam Hayat5

1Department of Microbiology, Kohat University of Science and Technology, Kohat 26000, Khyber Pakhtunkhwa
2Department of Molecular Biology and Genetics, Izmir Institute of Technology, Urla, Izmir 35000, Turkey
3Department of Biotechnology and Genetic Engineering, Kohat University of Science and Technology, Kohat 26000, Khyber Pakhtunkhwa, Pakistan
4Department of Zoology Kohat University of Science and Technology, Kohat, 26000, Khyber Paktunkhwa, Pakistan
5Department of Microbiology, Abbottabad University of Science and Technology, Havelian, Abbottabad
6Department of Microbiology, Hazara University, Mansehra, Dhodial, Khyber Pakhtunkhwa, Pakistan
7Center for Human Genetics, Hazara University, Mansehra, Dhodial, Khyber Pakhtunkhwa, Pakistan

 

*     Corresponding author: salupakhtoon@gmail.com

ABSTRACT
Hepatitis B viral (HBV) infection is a major health problem globally and more prevalent in Pakistan, which is the main etiological agent of chronic hepatitis B, hepatocellular carcinoma and liver cirrhosis. A total of 659 HBsAg ELISA positive patients out of 16825 patients during July to October, 2013 were screened for HBV by real-time polymerase chain reaction. Out of 659, 522 (79.21%) were found positive for HBV, of which 318 (over all 4.4%) were male, while 341 (over all 3.55%) were female. The HBV PCR positivity rate was 80.18% (n=255) in males and 78.30% (n=267) in females patients. Among different age groups HBV PCR positivity was highest (n=181, 83.41%) in the age group of 31 to 40 years. HBV genome was detected in 79.21% of HBsAg positive samples, showing that HBsAg on ELISA is much more sensitive than PCR as HBV shows chronic conditions and both of the tests are needed against HBV.

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Pakistan Journal of Zoology (Associated Journals)

June

Vol. 49, Iss. 3, Pages 761-1149

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