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Molecular Effects of Polymorphism in the 3'UTR of Osteopontin Gene in Riverine Buffalo

Molecular Effects of Polymorphism in the 3'UTR of Osteopontin Gene in Riverine Buffalo

Sidra Manzoor1,Asif Nadeem1,*, Masroor Ellahi Babar2, Wasim Shehzad1, Abu Saeed Hashmi1, Muhammad Imran1, Tanveer Hussain2, Abdul Wajid&

1Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore, Pakistan
2Virtual University of Pakistan, Lahore, Pakistan

 

*     Corresponding author: asifnadeem@uvas.edu.pk

ABSTRACT
Nucleotide sequencing of bovine osteopontin gene showed a novel DNA polymorphism 37421762 (C>A) in the 3’-untranslated region (3’-UTR) of the gene. Association test was performed to analyze its relation with milk composition but it was found non-significant in all analyzed traits. So, it was inferred that it might be due to environmental or epigenetic effect, sampling number or a breed difference. To know the functional consequences of the identified polymorphism, RNA secondary structure analysis was performed and SNP was found changing the termination loop shape in mRNA. However, to increase the selection efficacy of dairy animals, the effects of candidate polymorphism should further be screened in different environments and genetic backgrounds.

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Pakistan Journal of Zoology (Associated Journals)

August

Vol. 49, Iss. 4, Pages 1151-1546

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