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Genotoxic Evaluation of an Endemic Plant Thermopsis turcica Extracts on Liver Cancer Cell Line

Genotoxic Evaluation of an Endemic Plant Thermopsis turcica Extracts on Liver Cancer Cell Line

Muhammad Muddassir Ali1,2 and İbrahim Hakkı Ciğerci1,*

1Department of Molecular Biology and Genetics, Faculty of Science and Literature, Afyonkocatepe University, Afyonkarahisar 03200, Turkey.
2Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore, Pakistan

*     Corresponding author: cigerci@aku.edu.tr

 

ABSTRACT
Traditional medicines are used for therapeutic purposes all over the world. Many endemic plants all over the world have magical therapeutic potential. These could be explored further for medicinal purposes and hence can be preserved for their proper propagation. Thermposis turcica is endemic to Turkey. It’s general anti-oxidant and anti-cancerous activities are explored, but no study has been observed on liver cancerous cell line in term of its genotoxicty. So, genotoxic evaluation was carried out for the alcoholic and hexane extracts of T. turcica. Methanol extracts showed the highest DNA damage (20±1) at 200 µg/ml concentration and 11.67±2.52 at 50 µg/ml. Ethanol extracts showed the 2nd highest DNA damage (19±2)at 200 µg/ml concentration and 11 ±1at 50 µg/ml. While least was observed in the hexane extract (10.33±1.15; 6±2) at both concentrations, respectively. All groups were significantly different (P<0.05) from the control group at both concentrations. A current study concluded that T. turcica had the genotoxic effects on the liver cancerous cell line and alcoholic extracts showed the more DNA damage on HepG2 cells.

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Pakistan Journal of Zoology

December

Vol. 50, Iss. 6, Pages 1999-2398

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