Effect of GABAB Receptor Antagonist (CGP55845) on the Hematological and Serum Biochemical Profile of Adult Male Albino Mice
Rabia Qurashi, Qurat ul Ane Gillani* and Furhan Iqbal*
Present study was conducted to report the effect of 1mg / ml of solvent / Kg body weight GABAB receptor antagonist (CGP55845; 3-N [1-(S)-(3,4- dichlorophenyl) ethyl] amino-2-(S)- hydroxypropyl-P-benzyl-phosphinic acid), intraperitoneally injected for 12 days, on hematological and serum biochemical profile of 6 week old male albino mice. Blood samples from male albino mice (CGP55845 treated N = 14 and saline treated N = 16) were collected directly by cardiac puncture and used for estimation of hematological and some serum biochemical parameters. The hematological parameters did not show any significant variation between the two groups. From amongst serum biochemical parameters triglycerides (P = 0.02) in CGP55845 treated mice showed significant increase compared to the control mice. All other studied parameters remained unaffected indicating that CGP55845 can be injected intraperitonially for the treatment of neurological ailments.