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Effect of GABAB Receptor Antagonist (CGP55845) on the Hematological and Serum Biochemical Profile of Adult Male Albino Mice

Effect of GABAB Receptor Antagonist (CGP55845) on the Hematological and Serum Biochemical Profile of Adult Male Albino Mice

Rabia Qurashi, Qurat ul Ane Gillani* and Furhan Iqbal*

Institute of Pure and Applied Biology, Zoology Division, Bahauddin Zakariya University, Multan 60800, Pakistan

Rabia Qurashi and Qurat ul Ane Gillani contributed equally to the manuscript.

*     Corresponding authors: anneegillani@gmail.com; 
furhan.iqbal@bzu.edu.pk

ABSTRACT
Present study was conducted to report the effect of 1mg / ml of solvent / Kg body weight GABAB receptor antagonist (CGP55845; 3-N [1-(S)-(3,4- dichlorophenyl) ethyl] amino-2-(S)- hydroxypropyl-P-benzyl-phosphinic acid), intraperitoneally injected for 12 days, on hematological and serum biochemical profile of 6 week old male albino mice. Blood samples from male albino mice (CGP55845 treated N = 14 and saline treated N = 16) were collected directly by cardiac puncture and used for estimation of hematological and some serum biochemical parameters. The hematological parameters did not show any significant variation between the two groups. From amongst serum biochemical parameters triglycerides (P = 0.02) in CGP55845 treated mice showed significant increase compared to the control mice. All other studied parameters remained unaffected indicating that CGP55845 can be injected intraperitonially for the treatment of neurological ailments.

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Pakistan Journal of Zoology

October

Vol. 50, Iss. 5, Pages 1601-1998

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