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Fennel Oil Treatment Mimics the Anti-Depressive and Anxiolytic Effects of Fluoxetine without Altering the Serum Cholesterol Levels in Rats

Fennel Oil Treatment Mimics the Anti-Depressive and Anxiolytic Effects of Fluoxetine without Altering the Serum Cholesterol Levels in Rats

Tahira Perveen1,*, Shaista Emad1, Saara Ahmad2, Zehra Batool1, Sarwat Yousuf1, Sheeza Sheikh1, Sara Qadeer1 and Saida Haider1

1Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi 75270, Pakistan
2Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi, Pakistan

*      Corresponding author: tahiraatiq@hotrmail.com;  tperveen@uok.edu.pk

Fig. 1.

Comparative effects of fluoxetine and fennel oil rats was assessed by forced swim test (A), open field test (B) and elevated plus maze (C). Values are means+SD (n = 8). Significant differences by Bonferroni test: *p<0.05, **p<0.01 from respective control animals; +p<0.05, ++p<0.01 from week one values of similarly treated animals following two-way ANOVA repeated measure design.

Fig. 2.

Effects of fluoxetine and fennel oil administration for three weeks on serum cholesterol levels. Values are means+SD (n = 8). Significant differences by Tukey’s post-hoc test: **p<0.01as compared to controls following one-way ANOVA.
 

Pakistan Journal of Zoology

June

Vol. 50, Iss. 3, Pages 799-1198

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