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Whole Cell SELEX Technology and its Applications

Whole Cell SELEX Technology and its Applications

Neha Singh and Anjana Pandey

 Department of Biotechnology, Motilal Nehru National Institute of Technology Allahabad, Allahabad-211004 (U.P.), India.

Email: anjanap@mnnit.ac.in

ABSTRACT

 SELEX is an in vitro selection procedure to evolve single-stranded nucleic acids known as aptamers. Aptamers are known for their high selectivity and specificity and their ability to form 3D conformations. CELL SELEX is a modification of SELEX where instead of using purified ligand molecules, whole live cells are used as targets, so the aptamers being generated could bind target molecules on live cells in their native conformation and it is possible to know the molecular profile of the cellular surface. Whole CELL SELEX is very useful in the field of diagnostics and targeted therapy and the aptamers generated can be utilized to differentiate cancerous cells from normal cells or even different types of cancerous cells, detect live pathogenic organisms, and to discover novel disease biomarkers to facilitate early detection of the disease and for therapeutic purposes.

 

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Aptamers and Synthetic Antibodies

June

Vol.2, Iss.1, Page 1-35

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