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Variation in Physiological Biomarkers with Different Clostridium perfringens Isolate Infections in Balkhi Sheep

Variation in Physiological Biomarkers with Different Clostridium perfringens Isolate Infections in Balkhi Sheep

Mumtaz Ali Khan1, Sher Bahadar Khan2, Shakoor Ahmad2, Irshad Ahmad3, Kashif Prince1*, Ghazunfar Rashid1, Mahboob Ali1, Imdad Ullah Khan4Asad Ullah5, Naimat Ullah4, Muhammad Shoaib2 and Said Sajjad Ali Shah2

1University of Veterinary and Animal Sciences, Lahore
2Department of Animal Health, The University of Agriculture, Peshawar
3Instutute of Basic Medical Sciences, Khyber Medical University, Peshawar
4Gomal College of Veterinary Sciences, Gomal University, D.I. Khan
5College of Veterinary Sciences and Animal Husbandry, Abdul Wali Khan University, Mardan

*      Corresponding author: kashif_prince@live.com

ABSTRACT

The objective of this study was to determine variations of different physiological biomarkers in Clostridium perfringens (CP) infections in Balkhi breed of sheep in Khyber Pakhtunkhwa, Pakistan. Study was conducted on 184 sheep suspected of having enterotoxemia and 107 sheep were identified to be infected with Clostridium perfringens. Genotypic Analysis of all isolates from infected sheep was performed. Results showed, 53.27% isolates showed infection of CP type A, 10.28% of type B and 36.44% of type D. Animal infected with different serotypes (A, B, and C) were categorized into two groups healthy and diseased to compare the hematological and biochemical parameters. Hematobiochemical analysis indicated that mean erythrocyte count (RBC) and hemoglobin levels decreased while the mean leukocytes (WBC), platelets, packet cell volume (PCV) and total bilirubin levels increased significantly (P<0.05) in sheep infected with Clostridium perfringens type A. Sheep infected with Clostridium perfringens type B and type D showed significant (P<0.05) decreases in erythrocytes counts (RBC) and hemoglobin levels while the mean WBC, platelets, packet cell volume, serum creatinine, bilirubin, liver enzymes, total, glucose and urea in blood significantly (P<0.05) increased. Fluctuations in mean erythrocyte counts (RBC), hemoglobin, PCV and total bilirubin were beyond the limits while others were within normal ranges in sheep infected with Clostridium perfringens type A. The total bilirubin, Liver enzymes, creatinine level, glucose and urea levels in blood were abnormal while others were within normal ranges in sheep infected with CP type B and type D. by observing these changes it will be possible to diagnose disease at initial stages.
 

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Pakistan Journal of Zoology

December

Vol. 52, Iss. 6, Pages 2027-2426

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