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Use of Suppression Subtractive Hybridization for Viral Diagnostics

Use of Suppression Subtractive Hybridization for Viral Diagnostics

Mohammed M. Islam1, 3 *, Damian F. J. Purcell2 and George Kannourakis1,3

1Fiona Elsey Cancer Research Institute, 106-110 Lydiard Street South, Ballarat Technology Park Central, Ballarat, VIC 3353, Australia; 2Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria 3010, Australia; 3School of Applied and Biomedical Sciences, Federation University, Victoria, 3350, Australia.

Email: monirul@fecri.org.au

ABSTRACT

Efficient identification of viruses is paramount to not only define the cause of uncharacterized infections but also to estimate the dynamics of viral population in the infected hosts. Several recent methodologies and chemistries have been proposed for viral diagnostics with variable outcomes and successes. In this review, we discuss a novel approach to identify the least transcripts of viral genomes using suppression subtractive hybridization that can be adapted to unanimously identify viruses of diverse genetic backgrounds. 

 

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Hosts and Viruses

June

Vol.6, Iss.3, Pages 42-84

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