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UVB Irradiation Induces Human Skin Fibroblasts Senescence Through Regulate Β-Catenin and Smp30 Expression

UVB Irradiation Induces Human Skin Fibroblasts Senescence Through Regulate Β-Catenin and Smp30 Expression

Feng-Mei Yang1, Rui Li2, Xiu-Xue Hu3, Yong Liang4, Bo Gao3* and Wei Chen3*

1Departments of Obstetrics and Gynecology, Taihe Hospital, Hubei University of Medicine, Shiyan, Renmin Southern 32, Hubei 442000, P.R. China 
2Department of Medical offices, Taihe Hospital, Hubei University of Medicine, Shiyan, Renmin Southern 32, Hubei 442000, P.R. China
3Department of Laboratory Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan, Renmin Southern 32, Hubei 442000, P.R. China
4Department of Anesthesiology, Ren-ming Hospital of Yun-xi, Shiyan, Hubei 442000, P.R. China
 
*      Corresponding author: typing1216@hotmail.com; 248369577@qq.com

Fig. 1.

The changes of every detection indicator with different UVB doses for different durations. a, cell proliferation inhibition rate, CPIR; b, apoptosis rate; c, β-catenin mRNA expression; d, SMP30 mRNA expression.

Fig. 2.

The changes of HSF apoptosis with different UVB doses for different durations. A, different doses UVB treatment 1 day; B, different doses UVB treatment 2 day; C, different doses UVB treatment 3 day.

Fig. 3.

Analysis of the relationship between every detection indicator and different UVB doses for different durations by Bilinear regression. a, cell proliferation inhibition rate (CPIR); b, apoptosis rate; c, β-catenin; d, SMP30), P<0.05.

Fig. 4.

The expression ofβ-catenin and SMP30 mRNA /protein in every group. A, gene expression products by PCR: 1, control group; 2, GAPDH; 3~5, β-catenin; 6~8, SMP30; 9, Marker. B, protein expression products by Western Blot.

Pakistan Journal of Zoology

October

Vol. 52, Iss. 5, Pages 1631-2026

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