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Therapeutic Evaluation of Fipronil and Doramectin against Brown Tick Infestation of Dogs

Therapeutic Evaluation of Fipronil and Doramectin against Brown Tick Infestation of Dogs

Wael Felefel1*, Mohamed EL-Beskawy2, M. F. El -Dakroury3, Mohamed Morsi Elkamshishi4, Eman Sayed Mohammed5 

1Department of Parasitology, Faculty of Veterinary Medicine, Matrouh University, Matrouh 51744, Egypt; 2Departement of Animal Medicine, Faculty of Veterinary Medicine, Matrouh University. Matrouh 51744, Egypt; 3Department of Pharmacology, Faculty of Veterinary Medicine, Matrouh University, Matrouh 51744, Egypt; 4Department of Animal Hygiene and Zoonoses, Faculty of Veterinary Medicine, Matrouh University, Matrouh 51744, Egypt; 5Department of Parasitology, Faculty of Veterinary Medicine, South Valley University, Qena 83522, Egypt.

*Correspondence | Wael Felefel, Department of Parasitology, Faculty of Veterinary Medicine, Matrouh University, Matrouh 51744, Egypt; Email: waelfelefel@yahoo.com 

ABSTRACT

Hard ticks are ectoparasites which have a permanent relationship with their hosts. Ticks are spread of a variety of diseases that affect a wide range of animal hosts. In the current study, the acaricidal efficacy of topical Fipronil was evaluated compared to that of Doramectin injection on naturally infested dogs with hard ticks. Forty five stray dogs with age above 6 months were collected from Alexandria governorate with heavy or moderate ticks infestation. The captured dogs were divided into 3 groups, each group includes 15 dogs, and categorized as follows; group (1): (Positive control group), group (2): (Doramectin injected group), and group (3): (topical Fipronil group). It was observed that the overall complete curative rate was 60.00% in group 2 and 33.33% in group 3. Marginal Homogeneity test showed that there was a statistically insignificant difference between intervention groups pre and post-treatment as in group 2 (P=0.631) and group 3 (P=0.144). Furthermore, evaluating the efficacy of treatment using ROC curve showed that group 2 has a higher area under curve (AUC =0.742) than group 3 (AUC= 0.483). Both drugs were successful in controlling ticks in dogs, but Doramectin injection made a perceived influence on tick treatment in heavy infestation cases. In addition, Doramectin was found to be safer where it improved kidney and liver function tests in addition to the velocity of killing ticks with injection.

Keywords | Doramectin, Fipronil, Hard Ticks, Stray dogs, ROC curve  

 

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Advances in Animal and Veterinary Sciences

June

Vol. 10, Iss. 6, Pages 1189-1422

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