Submit or Track your Manuscript LOG-IN

Therapeutic Effects of Curcuma longa against Rotenone-Induced Gross Motor Skill Deficits in Rats

Therapeutic Effects of Curcuma longa against Rotenone-Induced Gross Motor Skill Deficits in Rats

Syeda Madiha, Zehra Batool, Saiqa Tabassum, Laraib Liaquat, Sadia Sadir, Tahira Perveen and Saida Haider*

 

Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi 75270, Pakistan

*      Corresponding author: saida-h1@hotmail.com

 

ABSTRACT

Rotenone (pesticide and mitochondrial complex I inhibitor) has been associated to induce toxicity in humans and as well as in animals. The present study evaluated the protective role of curcumin against rotenone-induced motor deficits, biochemical and neurochemical alterations. Rotenone was injected subcutaneously at the dose of 1.5 mg/kg for 8 days. Supplementation of curcumin (100 mg/kg/day, p.o.) was started before 15 days of rotenone injection. The effects of curcumin pre-treatment were evaluated by different motor behavioral parameters (pole test, Kondziela’s inverted screen test, inclined plane test, open field test, beam walking test and footprint test). Biochemical and neurochemical alterations were also monitored. Pre-treatment with curcumin reversed the motor impairments, biochemical and neurochemical alterations which were produced by rotenone. Furthermore, curcumin treatment restored the dopaminergic and cholinergic functions. We conclude that curcumin prevent against toxic effect of rotenone and can be beneficial against different neurodegenerative diseases.
 

To share on other social networks, click on P-share. What are these?

f

Pakistan Journal of Zoology

June

Vol. 50, Iss. 3, Pages 799-1198

Featuring

Click here for more

Subscribe Today

Receive free updates on new articles, opportunities and benefits


Subscribe Unsubscribe