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The Oral Administration of Elastin Peptide Reduces Ultraviolet Light-Induced Photoaging in Hairless Mice

The Oral Administration of Elastin Peptide Reduces Ultraviolet Light-Induced Photoaging in Hairless Mice

Zheng Yan1,2,*, Shuang Liu2, Ai-Qing Liu2 and Hai-Yan Wang2

1College of Bioengineering, Beijing Ρolytechnic, Beijing 100176, China
2Beijing Semnl Biotechnology Co., Ltd., Beijing 100062, China

 https://dx.doi.org/10.17582/journal.pjz/20200629020649

Fig. 1.

Effect of elastin peptide on elasticity of skin of UV induced photoaged hairless mice. A, Q1 = total elastic – plastic area of the spring – back component; B, R2 = total elastic – plastic amount of the rebound component. For comparisons between UV-irradiated controls and experimental groups. *, P< 0.05; **, P< 0.01; ***, P<0.001.

Fig. 2.

Effect of elastin peptide on collagen content of skin of UV induced photoaging hairless mice. A, Col-I; B, Col-III; C, Col-IV. For comparisons between UV-irradiated controls and experimental groups. *, P< 0.05; **, P< 0.01; ***, P<0.001.

Fig. 3.

Effect of elastin peptide on hydroxyproline (Hyp) content of skin of UV induced photoaging hairless mice. For comparisons between UV-irradiated controls and experimental groups. **, P< 0.01; ***, P<0.001.

Fig. 4.

Effect of elastin peptide on hyaluronic acid (HA) content of skin of UV induced photoaging hairless mice. For comparisons between UV-irradiated controls and experimental groups. ***, P<0.001.

Fig. 5.

Effect of elastin peptide on dorsal tissues of skin of UV induced photoaging hairless mice. A, normal group; B, UV induced group; C, low-dose group; D, middle-dose group; E, high-dose group. Staining, H&E; Magnification, ×400.

Pakistan Journal of Zoology

December

Vol. 53, Iss. 6, Pages 2001-2521

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