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Studies on Mechanism of Preventive Effect of Fermentation Product of Calvatia lilacina on Water-Immersion Stress Induced Gastric Ulcers in Mice

Studies on Mechanism of Preventive Effect of Fermentation Product of Calvatia lilacina on Water-Immersion Stress Induced Gastric Ulcers in Mice

De Hu, Jia Wang, Huan Wang, Xiang-Yang Leng, Tian-Yi Zhao* and Shu-Min Wang*

College of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, PR China.

 
* Corresponding author: zhaoty@ccucm.edu.cn; wangsm@ccucm.edu.cn

ABSTRACT

To explore the potential mechanism of the fermentation product (FP) of Calvatia lilacina on gastric ulcer, fifty mice were randomly divided into 5 groups (10 mice per group), namely control (normal saline), model (normal saline), ranitidine group (0.03 g/kg) and FP groups (1 and 2 g/kg). Stress gastric ulcer was induced by water-immersion and restraint stress (WIRS) after 10 days of drug administration. To observe the histopathological changes of gastric mucosa. the activities of pepsin, superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO) in gastric tissue and the levels of tumor necrosis factor (TNF–α) and interleukin (IL-6) in serum were measured through ELISA, and the contents of NLRP3, ASC, caspase-1 and IL-1β in gastric tissue were detected by Western blot. The results showed that FP of C. lilacina could effectively prevent the stress gastric ulcer induced by WIRS in mice by reducing the expression level of NLRP3/ASC/caspase-1.

 

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Pakistan Journal of Zoology

August

Vol. 54, Iss. 4, Pages 1501-2001

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