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Structural Characterization and Evolutionary Analysis of Toll-Like Receptor Gene Family in African Hunting Dog

Structural Characterization and Evolutionary Analysis of Toll-Like Receptor Gene Family in African Hunting Dog

Huanxin Zhang1,2, Hongshuo Tang3, Jun Chen1, Yu Zang1,2, Xuexi Tang1,2,* and Ying Wang1,2,*

1College of Marine Life Sciences, Ocean University of China, Qingdao 266100, China
2Laboratory of Marine Ecology and Environmental Science, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China
3College of Information Science and Engineering, Ocean University of China, Qingdao 266100, China

*      Corresponding authors: tangxx@ouc.edu.cn; ywang@ouc.edu.cn

 

ABSTRACT

The innate system plays a major role in the recognition of microbial component. Mammalian toll like receptor (TLR) were evolutionary conserved protein and have contributed to the understanding of the host defense processes against infection. Researches have been performed on the evolution in many species, but the evolutionary characteristics of African hunting dog TLR genes are scared. The available genome sequence of African hunting dog offers us the way to examine the innate immunity of this endangered carnivore. 10 TLR genes (TLR1-10) were initially identified from the African hunting dog and lesser panda. The results showed that most of the TLR genes were very conservative in the African hunting dog. We found 6 of ten TLR genes had the evidence of positive selection, only a small proportion of sites show evidence of selection, ranging from 0 to 9. In the present study, only four and three common positive selection codons were identified in rabies virus associated TLRs (TLR3 and TLR7); we speculated that the virus associated TLRs were mainly under purifying selection. In conclusions, the TLR genes were mainly shaped by purifying selection, and the limit number of positive selection codons may be resulted from ancient functional adaptation in the carnivores.
 

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Pakistan Journal of Zoology

April

Vol. 52, Iss. 2, Pages 425-824

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