Bacterial wilt [c.o. - Ralstonia solanacearum (Smith) Yabuuchi et al.] is one of the threatening potato diseases. To study the effect of some disease management practices in potato, an investigation was conducted in slightly acidic (pH 5.62) loamy sand soil with medium fertility status in a Randomised Block Design with three replicates and seven treatment modules, as described in Materials & Methods. Investigation revealed that T1 (TPS whole tuber planting) and T4 (supervised management - cowdung @ 40 ha-1 at land preparation + seed piece tuber treatment with carbendazim 2.5 gL-1 and Streptocycline @ 1 gL-1 + stable bleaching powder drenching with out removal of affected plant at 40 Days After Planting (DAP) @ 10 gL-1, along with protective banding with well decomposed cowdung + oilcake + Single Super Phosphate + Muriate of Potash mixture at 20:5:3:1 in each bacterial wilt affected plant + mancozeb spray @ 2.5 gL-1 at 50, 57 and 60 DAP) were the best treatment in terms of their responses to yield, disease management and higher return per rupee investment. The highest tuber yield and low disease intensity was obtained from T1 (TPS whole tuber planting) followed by T4 (supervised management) but under congenial condition for a particular disease like bacterial wilt, it may not possess same result as obtained in the experiment. One of the major advantages of TPS whole tuber planting includes the lack of incipient infection of bacterial wilt pathogen in seed tuber. Therefore, it is always desirable to obtain planting tuber from reliable source. So, integration between whole tuber planting or seed piece treatment units supervised management may offer better protection from the dreaded disease. Dynamic nature of disease management offers the scope for future modification.