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Schiff Base, 6-Amino-2-[(4-(Dimethylamino)Benzylidene)Amino]Hexanoic Acid and its Lanthanide (III) Complexes have Antioxidant and Antimicrobial Activities

Schiff Base, 6-Amino-2-[(4-(Dimethylamino)Benzylidene)Amino]Hexanoic Acid and its Lanthanide (III) Complexes have Antioxidant and Antimicrobial Activities

Mehwish Aftab, Tariq Mahmud*, Muhammad Asim Raza Basra, Aqsa Gulzar, Sumaira Basharat and H.M. Junaid

Institute of Chemistry, University of the Punjab, Lahore

*      Corresponding author: tariqm06@yahoo.co.uk

 

 

ABSTRACT

The titled Schiff base, 6-amino-2-[(4-(dimethylamino)benzylidene)amino]hexanoic acidwas synthesized by condensing N,N-dimethyl aminobenzaldehyde and Lysine together using ethanol as a solvent. The Schiff base was isolated and further reacted with Ce(NO3)3.6H2O and La(NO3)3.6H2O, to afford their respective complexes. FTIR, 1H NMR, UV-Vis and ICP techniques were used the characterization and structure elucidation of the prepared Schiff base and its La (III) and Ce (III) complexes. The proposed geometries of the complexes were established on the basis of metal ligand ratio through ICP. Schiff base showed antioxidant activity against diphenylpicrylhydrazyl (DPPH). The results showed that metal complexes are good antioxidant agents as compared to Trolox (standard) and ligand was less active as compared to Trolox. The Schiff base ligand and its metal (III) complexes showed antibacterial activity against E. coli, S. aureus by disc diffusion method and antifungal activity against Macrophomina phaseolina, Fusarium oxysporum. The metal (III) complexes are highly active under permissible limits.
 

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Pakistan Journal of Zoology

December

Vol. 50, Iss. 6, Pages 1999-2398

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