Submit or Track your Manuscript LOG-IN

Safety Profile for Evaluation of Berberine in Sprague- Dawley Rats: Effects on Renal, Liver and Myelopoietic Functions

Safety Profile for Evaluation of Berberine in Sprague- Dawley Rats: Effects on Renal, Liver and Myelopoietic Functions

Attia Anwar1, Sajida Malik2*, Zobia Usman1 and Sadia Chiragh3 

1Assistant Professor of Pharmacology, Faisalabad Medical University, Faisalabad; 2Associate Professor of Pharmacology, Allama Iqbal Medical College, Lahore; 3Professor of Pharmacology, Post Graduate Medical Institute (PGMI), Lahore.

drsajida12@hotmail.com 

ABSTRACT

The study was designed to investigate the effect of berberine toxicity on liver enzymes, renal function, serum uric acid and blood cell counts of Sprague-Dawley rats. For this purpose, twenty Sprague-Dawley rats were divided in two groups. Group A (n=10) was given distilled water and Group B (n=10) was supplemented berberine hydrochloride with dose of 75 mg/kg body weight/day. 24 weeks post-treatment, blood samples were collected by cardiac puncture from both groups and tested for Hb (%), WBC, RBC and platelet counts, SGPT, alkaline phosphatse, serum uric acid, blood urea and serum creatinine. All the numerical data were expressed as mean± SD. The values in two groups were analyzed with help of unpaired t-test. A p-value ˂ 0.05 was considered significant. After 24 weeks of treatment with berberine hydrochloride, no significant differences were observed in Hb%, platelet count, liver enzymes and RFTs between two groups. There was a significant increase in RBC count and reduction in serum uric acid and WBC count in experimental group as compared to control group. There were no significant untoward effects of berberine on platelet count, LFTs and RFTs of Spargue-Dawley rats except neutropenia. 

 

To share on other social networks, click on P-share. What are these?

Annals of King Edward Medical University

March

Vol. 24, Iss. 1, Pages 1-153

Subscribe Today

Receive free updates on new articles, opportunities and benefits


Subscribe Unsubscribe