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SOX9 Promotes Hepatocellular Carcinoma Progression through Targeted Regulation of HSPA1B

SOX9 Promotes Hepatocellular Carcinoma Progression through Targeted Regulation of HSPA1B

Jiangbo Shao1, Donglai Zhu2, Shengqiang Zou1, Guohong Ge1 and Ju Huang1*

1Department of Hepatosis, The Third People’s Hospital of Zhenjiang Affiliated Jiangsu University, Zhenjiang, Jiangsu 212005, China
2Department of Clinical Laboratory, The Third People’s Hospital of Zhenjiang Affiliated Jiangsu University, Zhenjiang, Jiangsu 212005, China
 
Jiangbo Shao and Donglai Zhu contributed equally to this work.
 
*      Corresponding author: fwzzyyx@126.com

ABSTRACT

Recent studies have demonstrated that SOX9 was highly expressed and played critical roles in increasing cancer stem cell expansion as well as decreasing sensitivity to the sorafenib therapy in hepatocellular carcinoma. In this study, the potential functions and mechanisms of SOX9 in promoting hepatocellular carcinoma progression were investigated through comprehensive bioinformatics analysis. We found that SOX9 mainly participated in heat stress response, protein folding as well as metabolism and biosynthesis of amino acid. SOX9 correlated with HSPA1B were negative to the progression in hepatocellular carcinoma patients. These results suggest that SOX9 participated in hepatocellular carcinoma progression through targeted regulation of HSPA1B that might provide novel insights in hepatocellular carcinoma therapy.

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Pakistan Journal of Zoology

December

Vol. 54, Iss. 6, Pages 2501-3000

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