Renal Dysfunction in Ischemic Stroke Subjects
Renal Dysfunction in Ischemic Stroke Subjects
Saima Sharif*, Farkhanda Manzoor, Tasnim Farasat, Shaugfta Naz and Raheela Tabasum
ABSTRACT
To determine whether decreased kidney function is a risk-factor in first-ever ischemic stroke. The study was conducted from Jan, 2013 to Jan, 2014 in Services and Jinnah Hospital Lahore, Pakistan. A total of 150 subjects were included in this study, divided into ischemic stroke group (n=100) and control (n=50). Kidney function estimation was done using serum creatinine and blood urea along with eGFR calculation by MDRD equation. Kidney dysfunction was defined as eGFR of <60 ml/min/1.73m2. Statistical analysis was donedone by using SPSS. The serum creatinine of ischemic stroke patients was found to be 2.41 mg/dl compared to 0.93mg/dl in controls. The blood urea in ischemic stroke group was 67.3 mg/dl in contrast to 34.6 mg/dl in controls. The eGFR in ischemic stroke patients was calculated to be 54.62ml/min/1.73m2, compared to 85.90 ml/min/1.73m2 for controls. Prevalence of eGFR <60 ml/min/1.73m2 in patients with stroke was 63%, significantly higher (p<0.05) than in controls. Moderate to severe reduction of eGFR in patients with ischemic stroke indicated renal impairment and kidney dysfunction. The risk of first ever ischemic stroke increases with low eGFR.
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