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Raphanus sativus L. Var. caudatus as an Analgesic and Antipyretic Agent in Animal Models

Raphanus sativus L. Var. caudatus as an Analgesic and Antipyretic Agent in Animal Models

Ishrat Younus1,2 and Afshan Siddiq1*

1Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi 
2Department of Pharmacology, Faculty of Pharmacy, Hamdard University, Karachi.
 
* Corresponding author: afshanpharma@gmail.com

ABSTRACT

Raphanus sativus L. Var. caudatus belongs to Radish plant has been reported for analgesic potential thus it might have antipyretic potential. The present investigation was undertaken to evaluate analgesic and antipyretic activities of ethanol extract of Raphanus sativus var. caudatus in albino mice. The analgesic and antipyretic activities were determined at three different doses (50, 100 and 200 mg/kg) using different pain models (writhing induced, tail flick) and yeast induced pyrexia tests, respectively. The extract exhibited significant (p < 0.05) in vivo analgesic and antipyretic potential in term of % writhes inhibition, increased latency time and reduced rectal temperature when compared with control. The extract displayed noteworthy analgesic and antipyretic capabilities especially at the dose of 200 mg/kg that are almost comparable with standard drug (aspirin). Although the finding of present investigation highlighted the medicinal importance of the plant but there is dire need to carry out the fractional extraction of crude extract with different solvents based on polarity to identify the active constituents with exact analgesic and antipyretic mechanistic action of Raphanus caudatus as well as clinical trials are required in future for medicinal use of the plant in humans.

 

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Pakistan Journal of Zoology

August

Vol. 54, Iss. 4, Pages 1501-2001

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