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Quercetin Modulates Aging Induced-Testicular Damage Via Increasing the Antioxidant Defense and the Immunolocalization of the Proliferating Cell Nuclear Antigen in Male Rats

Quercetin Modulates Aging Induced-Testicular Damage Via Increasing the Antioxidant Defense and the Immunolocalization of the Proliferating Cell Nuclear Antigen in Male Rats

Eman A. Al-Shahari1,2, Abdelhalim A. Alkhazendar3, Eman R. ElBealy4 and Abeer A. Alm-Eldeen3*

1Department of Biology, Faculty of Science and Arts, King Khaled University, Abha, KSA
2Department of Biology, Faculty of Science, Ibb University, Ibb, Yemen
3Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt
4Biology Department, College of Science for Girls, King Khaled University, Abha, KSA

*      Corresponding author: abeer.eldeen@science.tanta.edu.eg; abeer75875@hotmail.com

ABSTRACT

Aging is a natural process that affects testicular functions via increasing the oxidative stress. Quercetin, a polyphenolic, that has antioxidant activity. Therefore, this study was performed to examine the possible role of quercetin in modulating aging-induced testicular damage. Samples from 30-months old rats’ testis were examined before and after 200 mg of quercetin/Kg administration. Before quercetin administration, they showed an increase in the lipid peroxidation and 8-hydroxy-2’-deoxyguanosine while showed a decrease in the superoxide dismutase activity, testosterone level and sperm count and viability. Seminiferous tubules diameters were 84.3 ± 5.6 µm and their epithelium heights were 21.2 ± 3.4 µm. Only spermatogonia that were positively reacted with proliferating cell nuclear antigen (PCNA). After quercetin administration, they showed an improvement in the previous biochemical parameters. Seminiferous tubule diameters were 105.2 ± 2.1 µm and their epithelium heights were 26 ± 2.1 µm. Remarkably, spermatogonia, spermatocytes, spermatids and sertoli were positively reacted with PCNA. In conclusion, quercetin could modulate aging induced-testicular damage via increasing the antioxidant defense and the immunolocalization of the proliferating cell nuclear antigen.
 

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Pakistan Journal of Zoology

April

Vol. 53, Iss. 2, Pages 401-800

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