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Protective Effect of Compound Whole-Grain on High Fat and Cholesterol Diet-Induced Obesity and Lipid Accumulation in Rats

Protective Effect of Compound Whole-Grain on High Fat and Cholesterol Diet-Induced Obesity and Lipid Accumulation in Rats

Hong Zhang1, Shu-Fen Han2, Jing Wang1, Shao-Kang Wang1, Gui-Ju Sun1 and  Cheng-Kai Zhai1, *

1Department of Food and Nutrition, School of Public Health, Southeast University, Nanjing 210009, PR China
2Department of Food and Nutrition, School of Public Health, Soochow University, Suzhou 215123, PR China

* Corresponding author: 101011384@seu.edu.cn

 

Fig. 1.

Effect of compound whole-grain on serum lipid profiles and glucose levels in rats fed high-fat/cholesterol diet. Each value represents the means with their standard deviations for ten animals (n = 10 for each group). Bars without a common superscript letter indicate significant differences among groups (P<0.05). (A), TG, triacylglycerol; (B), TC, total cholesterol; (C), HDL-C, high-density lipoprotein cholesterol; (D), glucose. For abbreviations, see Table I.

Fig. 2.

Effect of compound whole-grain on protein expression of SREBP-1c and PPAR-γ in liver and epididymal adipose tissues of rats fed high-fat/cholesterol diet by western blot. The intensity of the bands was quantified by densitometric analysis and normalized with corresponding β-actin (n = 5 for each group). For abbreviations, see Table I.

Fig. 3.

Effect of compound whole-grain on relative mRNA abundance of FAS (A) and ACC (B) in liver tissue of rats fed high-fat/cholesterol diet. The steady-state mRNA concentrations of FAS and ACC were quantified with real-time PCR and 2-△△Ct values were calculated to obtain fold expression levels. GAPDH mRNA levels were similarly measured and served as a reference control for mRNA quality and quantity. Each value represents the means with their standard deviations for five animals. Bars without a common superscript letter indicate significant differences among groups (P<0.05). For abbreviations, see Table I.

Pakistan Journal of Zoology

August

Vol. 51, Iss. 4, Pages 1203-1598

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