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Protective Effect of Compound Whole-Grain on High Fat and Cholesterol Diet-Induced Obesity and Lipid Accumulation in Rats

Protective Effect of Compound Whole-Grain on High Fat and Cholesterol Diet-Induced Obesity and Lipid Accumulation in Rats

Hong Zhang1, Shu-Fen Han2, Jing Wang1, Shao-Kang Wang1, Gui-Ju Sun1 and  Cheng-Kai Zhai1, *

1Department of Food and Nutrition, School of Public Health, Southeast University, Nanjing 210009, PR China
2Department of Food and Nutrition, School of Public Health, Soochow University, Suzhou 215123, PR China

* Corresponding author: 101011384@seu.edu.cn

 

ABSTRACT

To evaluate the effects of compound whole grains on high fat and cholesterol diet-induced obesity and lipid accumulation in rats and the possible molecular mechanisms, 40 male Sprague-Dawley rats were randomly assigned to four different diets, including reference chow diet (RCD), high fat and cholesterol diet (HFCD), city diet (CD) and compound whole-grain diet (CWD). Serum lipid profiles and glucose level were examined after 8 weeks. The molecular mechanisms underlined the effects of CWD on lipid metabolism were investigated by western blot and real-time PCR. CD exhibited fat accumulation increasing, increase in serum triacylglycerol, total cholesterol, glucose and the decrease in high density lipoprotein cholesterol. However, CWD can improve blood lipid and blood sugar levels, and at the same time improve obesity and fat accumulation in rats. CWD significantly augmented the relative level of peroxisome proliferators-activated receptor γ (PPARγ) and suppressed the sterol regulatory element-binding protein 1c (SREBP-1c) protein expression in rats’ tissues. Compound whole-grain ameliorates diet-induced obesity and hyperlipidemia by enhancing PPARγ and reducing SREBP-1c in rats. 
 

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Pakistan Journal of Zoology

October

Vol. 51, Iss. 5, Pages 1599-1997

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