Prevalence of Proinflammatory Cytokines in Relation to Chronic Obstructive Pulmonary Disease in Faisalabad District
Prevalence of Proinflammatory Cytokines in Relation to Chronic Obstructive Pulmonary Disease in Faisalabad District
Rida Younas1*, Tamseela Mumtaz1, Nabeela Roohi2 and Muhammad Amir Iqbal3
ABSTRACT
Chronic obstructive pulmonary disease (COPD) is the major cause of morbidity and mortality around the world. Evaluation of expressed of proinflammatory cytokine and chemokine as biomarker was obtained in moderate, severe and very severe COPD patients and established their relationship with lung obstruction. Samples were collected between April and August 2017, total 35 COPD patients with lung obstruction (FEV1/FVC< 70) were enrolled as well as age and sex matched healthy subjects were also recruited as control group. Expression of IL-6 and IL-8 in serum samples were evaluated by Enzyme-linked immunosorbent assay. Correlation between serum inflammatory cytokines (IL-6 and IL-8) level and post predicted FEV1%, FVC% and FEV1/FVC was analyzed. Results of serum IL-6 and IL-8 showed significant difference among control and GOLD stages II, III and IV (both P< 0.05). The level of IL-6 was highest in GOLD stage II and lowest in stage III significantly (P< 0.05). However, serum IL-8 was highest in GOLD stage IV and lowest in control significantly (P< 0.05). Over left groups were not significantly different with each other (P> 0.05). Both IL-6 and IL-8 were negatively correlated with FEV1%, FVC% and FEV1/FVC. Our investigation suggested the level of serum IL-8 was elevated in COPD as compared to control and was associated with disease severity of COPD patients as compared to control. It may be potential biomarker for evaluation of disease severity.
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February
2021
Vol. 53, Iss. 1, Pages 1-400
