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Postprandial Anti-Diabetic Effects of Various Fractions of Fagonia indica Burm. f. by in vitro and in vivo Studies

Postprandial Anti-Diabetic Effects of Various Fractions of Fagonia indica Burm. f. by in vitro and in vivo Studies

Atiq-ur-Rehman1,2,*, Abida Latif1,*, Rukhsana Anwar1, Nasir Abbas1, Sajid Nawaz2 and Hamid Turab Mirza3

1University College of Pharmacy, University of the Punjab, Lahore
2Faculty of Pharmacy, The University of Lahore, Lahore
3Department of Computer Science, COMSATS Institute of Information Technology, Lahore

*      Corresponding authors: atiqurrehman10@gmail.com; Abidalatif43@yahoo.com

 

 

Fig. 1.

Inhibitory activities of various fractions of F. indica on α-amylase. The values are presented as mean ± SD of triplicates. Data was analyzed by one way ANOVA that is followed by Tukey’s Multiple Comparison Test. Statistical significant (*a P<0.05 and ***c P<0.001) results when n-hexane and n-butanol fractions respectively were compared with standard. Non-significant (P>0.05) results when chloroform and ethyl acetate fractions were compared with standard.

Fig. 2.

The effect of standard acarbose and chloroform fractions of F.indica on postprandial BGL in normal rats (A) and diabetic rats (B) by oral starch tolerance test. The data is expressed as mean ± SD (n=6). Significant (P<.05) reduction in BGL at 0.5 h by comparing chloroform fraction 500 mg/kg with that of control.

α-amylase inhibitor (%)

Pakistan Journal of Zoology

April

Vol. 51, Iss. 2, Pages 399-799

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