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Possible Antiproliferative Effect of Tolfenamic Acid on Human LNCaP Prostate Cancer Cell Lines

Possible Antiproliferative Effect of Tolfenamic Acid on Human LNCaP Prostate Cancer Cell Lines

Rıfat Ertekin1*, Mete Ozkurt1, Gokhan Kus2 and Selda Kabadere1

1Eskisehir Osmangazi University, Department of Physiology, Faculty of Medicine, Eskisehir, Turkey
2Anadolu University, Department of Health Programme, Faculty of Open Education, Eskişehir, Turkey

*      Corresponding author: rertekin@ogu.edu.tr

 

Fig. 1.

The effects of TA application in doses of 1, 5, 10, 25, 50 and 100 μM at 24th and 48th h upon LNCaP cell survival. Compared to control group, the results are: **, p < 0.01; ***, p < 0.001.

Fig. 2.

Determination of cell percentage of early apoptosis in cancerous LNCaP cells following TA application (A, Control; B, 25 μM; C, 50 μM; D, 100 μM) for 24 h with LNCaP with the flow cytometric method. Live cells FITC (-) / PI (-), early apoptotic cells (FITC (+) / PI (-), necrotic or late apoptotic cells FITC (+) / PI (+).

Fig. 3.

Determination of cell percentage of early apoptosis in cancerous LNCaP cells following TA application (A, Control; B, 25 μM; C, 50 μM; D, 100 μM) for 48 h with LNCaP. Live cells FITC (-) / PI(-), early apoptotic cells (FITC (+) / PI (-), necrotic or late apoptotic cells FITC (+) / PI (+).

Pakistan Journal of Zoology

June

Vol. 51, Iss. 3, Pages 801-1202

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