Thisstudyevaluated thephysiological effects of ethanolic leaf extracts of Duranta erecta (L) in 48 albino wistar rats, Rattus norvegicususingbiochemical and haematological indicesof toxicity. The data were subjected to two-way analysis of variance (ANOVA) with Duncan’s multiple comparison post hoc tests to compare the level of significance between control and experimental groups. Group A served as control in which no leaf extract was administeredwhilegroupsB,Cand Dwererespectively administered with200,300and400mg/kgbodyweightoftheethanolicleaf extractof D. erectabygastricintubation for28days. The flavonoid contents were higher in relative high abundance (+++) more than other constituents such as the cardiac glycosides, steroids, saponins, and tannins are moderate in abundance (other constituents such as the cardiac glycosides, steroids, saponins, and tannins that were moderate in abundance (++). There was a dose duration dependent (p < 0.05) decrease in RBC in all the groups. There were also duration-dependent decrease in MCV values obtained in this research as against duration and dose dependent increases in MCH, and MCHC.Aspartate aminotransferase,andalkaline phosphataseweresignificantly (p < 0.05) reducedin the groupstreated with 200 and 400 mg/kg bodyweight of the extract. The reduced significant activity of these markers suggest that the ethanolic leaf extract of D. erecta offered some protections against diseases related to the muscles. The significant reduction of AST level has further eliminated any leakage of the enzyme in the liver due to hepatic injury in the treated rats. Previous biochemical studies have also confirmed the non toxicity of the plant extract of D. erecta to the kidney.