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Non-polio Enterovirus Species C infection in AFP Cases and its Implication for the Emergence of Recombinant Circulating Vaccine-Derived Polioviruses

Non-polio Enterovirus Species C infection in AFP Cases and its Implication for the Emergence of Recombinant Circulating Vaccine-Derived Polioviruses

Adewumi Olubusuyi Moses1,2*, Faleye Temitope Oluwasegun Cephas,1,3, Ope-Ewe Oludayo Oluwaseyi1, Ibitoye Ibipeju Henrietta1, Arowosaye Abiola Opeyemi1, Adelowo Oluwatosin Deji1 and Adeniji Johnson Adekunle1,2,4 

1Department of Virology, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria; 2Infectious Diseases Institute, College of Medicine, University of Ibadan, Nigeria; 3Centre for Human Virology and Genomics, Department of Microbiology, Nigerian Institute for Medical Research, Lagos, Nigeria; 4WHO National Polio Laboratory, University of Ibadan, Ibadan, Nigeria.

adek1808@yahoo.com 

ABSTRACT

Using 40 faecal samples from acute flaccid paralysis (AFP) cases collected in 2019, we examined how coupling Enterovirus (EV) isolation in RD and MCF-7 cell culture with direct detection from clinical sample might impact our ability to detect non-polio EV Species C (NPESC) members in stool samples. In all, 20% (8/40) of all the samples screened had NPESCs and 50% (8/16) of the EVs detected were NPESCs. However, the RD cell line missed all NPESCs. Hence, RD cell line alone should not be used for EV isolation if the desire is to also isolate NPESC.  

 

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Hosts and Viruses

April

Vol. 7, Iss. 2, Pages 20-38

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