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Non-Monotonic Endocrine-Disrupting Effects of Bisphenol-A on Vitellogenin Expression in Juvenile Freshwater Cyprinid, Catla catla

Non-Monotonic Endocrine-Disrupting Effects of Bisphenol-A on Vitellogenin Expression in Juvenile Freshwater Cyprinid, Catla catla

Mehwish Faheem1,*, Saba Khaliq2 and Khalid Parvez Lone2

1Department of Zoology, Government College University, Lahore, Pakistan
2Department of Physiology and Cell Biology, University of Health Sciences, Lahore, Pakistan 

*         Corresponding author: mehwishfaheem@gcu.edu.pk; mehwish_faheem@hotmail.com

ABSTRACT

Endocrine-disrupting chemicals e.g. bisphenol-A can alter fish reproduction. Vitellogenin (vtg) is the egg yolk precursor and used as a biomarker for estrogenic endocrine disruption. To elucidate the endocrine-disrupting effect of bisphenol-A, juvenile Catla catla was exposed to graded concentrations of bisphenol-A (10,100,1000μg/l) for 14 days. BPA exposure strongly elevates vtg mRNA level in fish exposed to 100μg/l but at 1000 μg/l exposure of BPA, vtg level decreased compared to 100µg/l exposed fish. These results showed that BPA has estrogenic action and cause endocrine disruption in juvenile C. catla at environmentally relevant concentration. Moreover, these results also depict the non-monotonic, biphasic dose response to BPA. 
 

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Pakistan Journal of Zoology

December

Vol. 51, Iss. 6, Pages 1999-2399

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