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Mechanisms of Bushen Zhuyun Decoction Regulating Pituitary Cell GnRH Receptor and Downstream cAMP-PKA Signaling Pathway in Treating Infertility Due to Luteal Phase Defect

Mechanisms of Bushen Zhuyun Decoction Regulating Pituitary Cell GnRH Receptor and Downstream cAMP-PKA Signaling Pathway in Treating Infertility Due to Luteal Phase Defect

Bei Liu1, Yanli Hong1, Huifang Zhou1,*, Zhenzhen Cao1, Shuang Zhang1, Jing Jin1, Miao Jiang1, Cunsi Shen2 and Jianjian Ji2

1Affiliated Hospital, Nanjing University of Chinese Medicine, Nanjing, 210029, China
2The First Clinical School, Nanjing University of Chinese Medicine, Nanjing, 210023, China

Bei Liu and Yanli Hong have contributed equally to this work.

*    Corresponding author: zhouhuifang2011301@163.com

 

Fig. 1.

Comparison of mRNA and protein levels of GnRHR in RPC cells. A, mRNA levels of GnRHR in RPC cells; B, protein levels of GnRHR in RPC cells. *p<0.05 conpared to the blank group, #p<0.05 compared to the model-treated group.

Fig. 2.

Comparison of mRNA and protein levels of PKA in RPC cells. *p<0.05 compared to the blank(-) group, #p<0.05,*p>0.05 compared to the Cetrorelix(-) group. &p<0.05 compared to the blank(+) group, ##p>0.05 compared to the Cetrorelix(+) group.

Fig. 3.

Comparison of mRNA and protein levels of CREB and Egr-1 in RPC cells. *p<0.05 compared to the blank(-) group, #p<0.05, *p>0.05 compared to the Cetrorelix (-) group. &p<0.05 compared to the blank(+) group,##p>0.05 compared to the Cetrorelix (+) group.

Pakistan Journal of Zoology

June

Vol. 51, Iss. 3, Pages 801-1202

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