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Interaction of Strychni Semen Combined with Paeoniae Radix Alba after Transdermal Administration: Skin Permeation and Pharmacokinetics

Interaction of Strychni Semen Combined with Paeoniae Radix Alba after Transdermal Administration: Skin Permeation and Pharmacokinetics

Yun-Feng Liu, Yong-Mei Guan, Dan Chen, Jia-Le Chen, Chen Jin, Wei-Feng Zhu, Lu Wu and Li-Hua Chen*

Key Laboratory of Modern Preparation of Traditional Chinese Medicine of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, China.

*      Corresponding author: chlly98@163.com

 

Fig. 1.

Chemical structures of strychnine (a), brucine (b), and paeoniflorin (c).

Fig. 2.

In vitro mouse skin permeation profiles of paeoniflorin from different compatibility proportions.

Fig. 3.

Mean concentration-time profiles of the in vivo pharmacokinetic study after transdermal administration of different proportions of gels; (A): brucine in skin; (B): strychnine in skin; (C): brucine in brain; (D): strychnine in brain; (E): paeoniflorin in the skin; (F): paeoniflorin in the brain.

Pakistan Journal of Zoology

June

Vol. 52, Iss. 3, Pages 825-1224

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