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Induction of Nuclear Factor κB in Different First-Line Anti-tubercular Drug-induced Liver Injuries in Mice

Induction of Nuclear Factor κB in Different First-Line Anti-tubercular Drug-induced Liver Injuries in Mice

Yuhong Li1, Dongxue Wu1, Xue Wang1, Mi Zhang1, Hanyu Zhu1, Zhe Shi1 and Fumin Feng1,2*

1School of Public Health, North China University of Science and Technology, Tangshan, 063210, China
2College of Life Science, North China University of Science and Technology, Tangshan, 063210, China

*      Corresponding author: fm_feng@sina.com

Fig. 1.

Histopathological changes in the liver tissue of mice in each group. Comments: Mice were treated with vehicle for control or anti-tuberculosis drugs for 3, 5, 7, 10, and 15 days, and then liver samples were processed routinely and stained with H&E for morphologic evaluation (original magnification × 100). D: Control; H: isoniazid, R: rifampicin, Z: pyrazinamide, and HRZ: INH + RFP + PZA.

Fig. 2.

Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels of the different groups. Data are expressed as mean ± SD of n = 8 animals per group. *P<0.05.

Fig. 3.

MDA content and SOD activity in different groups. Data are expressed as mean ± SD of n = 8 animals per group. *P<0.05.
 

Fig. 4.

The mRNA and protein expression levels of NF-kB, IkB and TNF-α in different groups. Data are expressed as mean ± SD of n = 8 animals per group. *P<0.05.

Pakistan Journal of Zoology

October

Vol. 52, Iss. 5, Pages 1631-2026

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