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In vivo Anti-Diabetic Studies of Sulfonylurea-Sulfonamide Hybrids

In vivo Anti-Diabetic Studies of Sulfonylurea-Sulfonamide Hybrids

Tanveer Ahmad1, Tariq Mehmood1, Muhammad Shahid1, Adnan Ahmad1,2, Muhammad Asim Raza Basra1, Muhammad Zia-ur-Rehman3* and Munawar Ali Munawar1

1Institute of Chemistry, University of the Punjab, Quaid-e-Azam Campus, Lahore-54590, Pakistan
2Key Laboratory of Synthetic and Natural Functional Molecular Chemistry of Ministry of Education, Department of Chemistry and Materials Science, Northwest University, Xi’an 710127, China
3Pakistan Council of Scientific and Industrial Research Laboratories Complex, Lahore-54000, Pakistan

*      Corresponding author: rehman_pcsir@hotmail.com

 

Fig. 1.

Chemical structures of selected anti-diabetic drugs.

Fig. 2.

Synthesis of sulfonylurea-sulfonamide hybrids.

Fig. 3.

OGTT activity of the compounds 3a-3g and 4a-4g. Oral glucose tolerance test was performed for the synthesized compounds in SD rats at the dose of 20mg/kg. Rats were orally administered with compounds 3a-3g and 4a-4g 30 min before the glucose dose (2 g/kg). The percentage reduction was noted at the interval 1, 2, and 5 hour of glucose dose (2 g/kg) and GC was used as reference drug.

Pakistan Journal of Zoology

June

Vol. 52, Iss. 3, Pages 825-1224

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