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In vivo Anti-Diabetic Studies of Sulfonylurea-Sulfonamide Hybrids

In vivo Anti-Diabetic Studies of Sulfonylurea-Sulfonamide Hybrids

Tanveer Ahmad1, Tariq Mehmood1, Muhammad Shahid1, Adnan Ahmad1,2, Muhammad Asim Raza Basra1, Muhammad Zia-ur-Rehman3* and Munawar Ali Munawar1

1Institute of Chemistry, University of the Punjab, Quaid-e-Azam Campus, Lahore-54590, Pakistan
2Key Laboratory of Synthetic and Natural Functional Molecular Chemistry of Ministry of Education, Department of Chemistry and Materials Science, Northwest University, Xi’an 710127, China
3Pakistan Council of Scientific and Industrial Research Laboratories Complex, Lahore-54000, Pakistan

*      Corresponding author: rehman_pcsir@hotmail.com

 

ABSTRACT

Owing to alarming increase of diabetes mellitus around the world, there is a need to discover new molecules to tackle with the problem. In this work, sulfonamides and sulfonylurea-sulfonamide hybrids were synthesized from simple molecule of 4-aminobenzenesulfonamide by its reaction with aryl sulfonyl chlorides. Anti-diabetic activities of these pharmacophores were studied by oral glucose tolerance test (OGTT) percentage analysis on Sprague Dawley (SD) rats at the dose of 20mg/kg using glibenclamide (GC). Among these synthesized pharmacophores, six compounds exhibited percentage reduction (20.47±2.54 to 44.97±2.16 %) and (20.79±1.55 to 37±2.94 %) in blood glucose level at 20mg/kg dose compared to glibenclamide (74±3.10 % reduction) 50mg/kg dose of glibenclamide after 2 and 5 hours of oral administration respectively. Present results showed that these compounds might be excellent addition in the drugs used to suppress the higher level of blood glucose level in diabetes mellitus.
 

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Pakistan Journal of Zoology

June

Vol. 52, Iss. 3, Pages 825-1224

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