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In-vitro Anticancer Activity of Copper (II) and Zinc (II) Complexes with Derived Schiff Base Ligands

In-vitro Anticancer Activity of Copper (II) and Zinc (II) Complexes with Derived Schiff Base Ligands

Qaisar Jamal1,Salman Ahmad1, Nazma Habib Khan1, Sobia Wahid1, Muhammad Ikram2, Sadia Rehman2, Syed Basit Rasheed1 and Akram Shah1,* 

1Department of Zoology, University of Peshawar, Peshawar, Khyber Pakhtunkhwa
2Department of Chemistry, Abdul Wali Khan University, Mardan, Khyber Pakhtunkhwa

*     Corresponding author: akram_shah@uop.edu.pk

 

Fig. 1.

Structure of test complexes with Schiff base derived ligands: A, NM-3 Tetrakis(2-{(E)-[(2-{[(Z)-(2-hydroxynapthyl)methylidene]amino}phenyl)imino]methyl}phenol)Copper(II). Formula: C28H18CuN2O2, Mol. Wt: 478gms. B, NM-4 Tetrakis (2-{(E)-[(2-{[(Z)-(2-hydroxynapthyl)methylidene]amino}phenyl)imino]methyl}phenol)zinc(II). Formula: C28H18N2O2Zn; Mol. Wt: 480gms.

Fig. 2.

Percent inhibition by THP1 cells (A) PBLs (B) against four concentrations of NM3, NM4 and miltefosine.

Pakistan Journal of Zoology

December

Vol. 50, Iss. 6, Pages 1999-2398

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