This project was designed to evaluate the impact of two commercial mycotoxin binders (Mycotox® and Mycofix® Plus 3.0) on the humoral immunity, lymphoid organs and growth performance of broilers. In this study, a total of 118 day-old broiler chicks were used, of which 108 were randomly divided into 6 groups (A to F) on day 14th. Aflatoxins derived from Aspergillus parasiticus were mixed in the feed measuring 150 ppb and fed to various broiler groups. Mycotoxin binders were also added into the feed and offered to group E and F from 14th-42nd day of age. The impact of mycotoxin binders on antibody titer against New Castle disease virus, feed consumption, weight gain, relative weights of lymphoid organs and feed conversion ratio (FCR) of broilers were investigated. Chicks fed aflatoxins (group B) alone manifested significantly reduced feed consumption, body weight gain and feed conversion ratio. However, no variation in weight gain and FCR was found between the controls (A, B and C) and mycotoxin binders fed groups (experimental group E and F). Significantly reduced geometric mean titer (GMT) was recorded for birds fed aflatoxins alone. However, difference in the calculated values of GMT for control group and birds fed toxin binders was not significant. Treatment related changes in organ body weight ratio of thymus, spleen and Bursa of fabricius of aflatoxins binders administered groups (groups E and F) were also significant compared with ones fed aflatoxins mixed feed (groups B and C). In conclusion, mycotoxin binders counteracted the deleterious effects of aflatoxins on antibody profile, weight gain, feed consumption and visceral organs of broilers suggesting that these agents can be potential ameliorators against aflatoxicosis in broilers.