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Impact of Hepatitis B Virus Infection in Patients with Liver Transplantation

Impact of Hepatitis B Virus Infection in Patients with Liver Transplantation

Shaikh Abdul Lateef, Zhou Lin, Wu Jian, Junjie Qian, Jonathan Hartanto Tan and Zheng Shusen*
 

Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, China.

shusenzheng@zju.edu.cn 

ABSTRACT

Hepatitis B virus (HBV) as a deadly viral pathogen and crucial challenge for mankind is directly involved in the progress of hepatocellular carcinoma (HCC) subsequently affecting 250 million human population. Due to the complex viral genome of HBV, complete recovery from hepatitis is not achieved. Epidemiologically, it has been classified into infectious and serum hepatitis. The pattern of disease progression manifests liver inflammation, chronic hepatitis and hepatocellular carcinoma. In this article, we present a comprehensive review characterizing the viral architecture, life cycle, infectivity mechanisms, immune escape strategies, disease epidemiology and preventive measures associated with HBV. The current antiviral therapeutics are not providing adequate protection against HBV. It is mandatory to characterize and devise novel antiviral therapies to control the spread of hepatitis  

 

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Pakistan Journal of Zoology

December

Vol. 51, Iss. 6, Pages 1999-2399

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