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Impact of Trigonella foenum-graecum Leaves Extract on Mice Hair Growth

Impact of Trigonella foenum-graecum Leaves Extract on Mice Hair Growth

Fariha Imtiaz1, Muhammad Islam1, Hamid Saeed2,*, Bushra Saleem1, Maryam Asghar1 and Zikria Saleem2

1Section of Pharmaceutical Chemistry, University College of Pharmacy, University of the Punjab, Pakistan 
2Section of Clinical Pharmacy, University College of Pharmacy, University of the Punjab, Pakistan

*      Corresponding author: hamid.pharmacy@pu.edu.pk

ABSTRACT

The aim of present study was to investigate hair growth promoting effects of extracts of Trigonella foenum-graecum leaves. The extracts of powdered leaves were obtained in various solvents (petroleum ether, chloroform, methanol, ethanol and distilled water) using hot and cold extraction methods. Phytochemical analysis of leaves was performed on powder and extracts of leaves using already reported methods. Mineral analysis was done using atomic absorption spectrophotometer. Hair growth promoting effects were examined using alopecia mouse model. Phytochemical analysis demonstrated the presence of higherquantities of carbohydrates, proteins and secondary metabolites in methanol compared to other extracting solvents. Moreover, only ethanol (5 and 10%) and petroleum ether (5%) demonstrated significant hair growth promoting effects (p < 0.05) compared to standard, i.e., 5% minoxidil and extracts in other solvents. Likewise, ethanol (5% and 10 %) and petroleum ether (5%) extract had significant impact (p < 0.05) on hair length in comparison to minoxidil, however, no significant differences were observed between ethanol (5% and 10%) extracts and minoxidil on mice hair diameter. Taken together, our data suggested that ethanol extracts of leaves of T. foenum-graecum had significantly higher growth promoting effects compared to standard, i.e., minoxidil. Thus, results from our study set the stage of further studies to identify the constituents in ethanol extracts, responsible for hair growth promoting effects.
 

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Pakistan Journal of Zoology

December

Vol. 51, Iss. 6, Pages 1999-2399

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