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Identification of Circulating miRNAs as Non-Invasive Biomarkers of Triple Negative Breast Cancer in the Population of Pakistan

Identification of Circulating miRNAs as Non-Invasive Biomarkers of Triple Negative Breast Cancer in the Population of Pakistan

 Jawaria Shaheen1, Samiah Shahid1, Sabahat Shahzadi2, M. Waheed Akhtar1,3 and Saima Sadaf1,*

 1Institute of Biochemistry and Biotechnology, University of the Punjab, Lahore-54590

2Mayo Hospital, Lahore
3School of Biological Sciences, University of the Punjab, Lahore-54590

*      Corresponding author: saima.ibb@pu.edu.pk

 

Fig. 1.

Scatter plots are representing high expression fold change in mir-376c, mir-155, mir-17a and mir-10b with significant p-value (p< 0.05).

Fig. 2.

Box and Whisker plots are showing stage, grade, tumour size, lymph nodes involvement and metastasis association with mir-155, mir-376c, mir-10b and mir-17a, respectively in TNBC patient’s plasma samples.

Fig. 3.

Receiving Operating Curves (ROC) representing AUC, sensitivity and specificity of mir-376c, mir-155, mir-17a and mir-10b and comparison of miRNA panel for the assessment of biomarkers diagnostic outcome in TNBC vs non-TNBC.

Pakistan Journal of Zoology

June

Vol. 51, Iss. 3, Pages 801-1202

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