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Human Cytomegalovirus Tegument Protein pUL23 Interacts with Capsid Protein pUL85

Human Cytomegalovirus Tegument Protein pUL23 Interacts with Capsid Protein pUL85

 Shaoling Lin and Jiamiao Hu

Department of Biotechnology, Jinan University, 510632, Guangzhou, P.R China; Faculty of Science, The Chinese University of Hong Kong, Hong Kong SAR, P.R China; Warwick Medical School, University of Warwick, CV2 2DX, Coventry, United Kingdom.

Jiamiao_hu@163.com

ABSTRACT

 The tegument protein pUL23 of human cytomegalovirus (HCMV) plays an important in the virus pathobiology, however, its role in viral assembly and replication is poorly defined. In this study we demonstrated that HCMV pUL23 interacts with an essential component of capsid, the minor capsid protein (mCP, pUL85). Interaction was determined and confirmed with yeast two-hybrid, GST pull-down and co-immunoprecipitation analyses. This interaction may serve as a link in the processes of HCMV capsidation and tegumentation. This study provides further evidences in the functions of tegument proteins in the assembly of HCMV virons.

 

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Hosts and Viruses

June

Vol.6, Iss.3, Pages 42-84

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