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Hormonal Fluctuations of Serum Prolactin and Gonadotropins in Autoimmune Thyroid Patients

Hormonal Fluctuations of Serum Prolactin and Gonadotropins in Autoimmune Thyroid Patients

Khayyam1*, Muhammad Zahid1, Naiz Ali2 and Qadeem Khan3

1Department of Zoology, Islamia College University Peshawar, Khyber Pakhtunkhwa, Pakistan 
2Department of Pharmacy, Institute of Basic Medical Sciences Khyber Medical University, Peshawar 
3Department of Zoology, Govt Post Graduate College Dargai, Malakand

*      Corresponding author:


The present study was conducted to find the hormonal variations resulted after the autoimmune thyroid disease. Out of total eighty two autoimmune thyroid patients 50 were Hashimoto’s thyroiditis patients (HT) (30 female, mean age=34±1.43 years, 20 males mean age =38.35±1.17 years) and control group included 35 individuals (20 females mean age=31.65±1.77years, 15 males mean age=37.93±2.561 years). The 32 Grave’s disease (GD) patients (24 females mean age=34.96± 2.18 years, 8 males mean age=33±5.385) while control included 20 females (mean age=32.3±2.28years) and 5 males (mean age=27.33±4.83years). The prolactin in HT females and males showed significantly high values (p=0.041, 0.025respectively) but follicle stimulating hormone was significantly low (p=0.0007) in female HT patients. Follicle stimulating hormone and Luteinizing hormone concentrations were higher than normal range in both male and female Grave’s disease patients. Prolactin and serum gonadotropin showed fluctuations in Hashimoto’s thyroiditis patients but in Grave’s disease patients only the gonadotropins showed abnormal values while prolactin was in the normal range. The study suggests that autoimmune thyroid diseases effect the pituitary-hypothalamic axis which needs to be further investigated to find the mechanism underlying it.

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Pakistan Journal of Zoology


Vol. 52, Iss. 5, Pages 1631-2026


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