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High Expression of MDR1 is Correlated with Poor Prognosis for Common Malignancies

High Expression of MDR1 is Correlated with Poor Prognosis for Common Malignancies

Bo Gao1,2, Fengmei Yang3, Wei Chen2, Xiaojia Song4, Xiaobo Liu5 and Dongmin Li1*

 1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, Shanxi 710061, P.R. China.

2Department of Laboratory Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.
3Department of Obstetrics and Gynecology,Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.
4Shiyan Prefecture Center for Disease Control and Prevention, Shiyan, Hubei 442000, P.R. China.
5Department of Gastroenterology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.
 
Bo Gao and Fengmei Yang contributed equally.
 
*      Corresponding author: lidongm@mail.xjtu.edu.cn

Fig. 1.

The relative expression levels of MDR1 in all tissues.

Fig. 2.

Recurrence time and survival time in different groups. PEOC: primary epithelial ovarian cancer; NSCLC: non-small cell lung cancer; MDR1: multidrug resistance 1; MDR1+: MDR1 positive group; MDR1-: MDR1 negative group.

Fig. 3.

The ROC analysis of MDR1 expression and tumor markers in the prognosis of common malignant tumor.

Fig. 4.

Survival curves of MDR1 mRNA-positive and negative patients. A: non-small cell lung cancer; B: colorectal cancer; C: primary epithelial ovarian cancer; D: gastric cancer; E:breast cancer.

Pakistan Journal of Zoology

October

Vol. 52, Iss. 5, Pages 1631-2026

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