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HIV Tat Regulates the Immune Responses Induced by Vaccines

HIV Tat Regulates the Immune Responses Induced by Vaccines

Ye Liu2, Yulong Cong2, Yiming Shao1*

1State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, 155 Changbai Road Changping District, Beijing 102206, China; 2Department of Clinical Laboratory, Chinese P. L. A. General Hospital, No. 28 Fuxing Road, Beijing 100853, China.

E-mail: yshao08@gmail.com; yulongc@263.net

ABSTRACT

As the crucial transcription activator of HIV, Tat has been considered as an important immunogen for HIV vaccine candidates for a long time. However, HIV Tat also plays immunoregulation roles in improving immune responses of vaccines. Herein, we review recent developments of HIV Tat as immunoregulator using for optimizing the efficacy of vaccines. By highlighting preclinical/clinical applications of Tat and its working mechanisms, this review exhibits the superior potential of Tat as immunoregulator on optimizing immune responses mediated by vaccines. These examples of selected studies will provide researchers some implications and inspirations for using HIV Tat to optimize immune responses of vaccines.

 

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Hosts and Viruses

June

Vol.6, Iss.3, Pages 42-84

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