Indigenous Aseel female chicken (120 birds) comprising of four varieties (Lakha, Mushki, Peshawari and Mianwali) was fed for 42-days experimental period on antibiotic and probiotic supplemented ration. The results showed that the female growth, weight gain, FCR and economics varied significantly for feed supplements as well as for chicken varieties (P<0.05). The chickens given feed with probiotic (@1g/kg of feed were of more economic value than those fed on antibiotic supplemented feed and control with highest live body weight of 183.58±6.31g gaining 143.13±6.37g weight, multiplying their weight 4.56±0.17 times over the initial body weight with feed intake of 668.82±31.11g showing most efficient FCR (4.67±0.25) with least mortality and highest net profit (Rs.1677, 0.35 cost benefit ratio). Among varieties, Mushki showed more economic value than rest of the varieties with highest live body weight of 169.78±8.23g, gaining 130.61±7.92g weight, multiplying their weight 4.41±0.22 times over the initial body weight with feed intake of 658.95±37.70g showing slightly less efficient FCR (5.09±0.47) with no mortality and highest net profit (Rs.1432, 0.44 CBR). Hence, the households and commercial farmers are suggested to prefer Mushki variety of Aseel chicken as attempt to produce Aseel females and probiotic supplementation would be of high economic viability for such flocks.