Among arid zone plant species, Jojoba (Simmondsia chinensis), being an evergreen, perennial, multi-stemmed, and multipurpose plant has attracted wide attention due to its economic value, potential by-products and ability to withstand vagaries of the desert environment. By realizing the economic importance of this high-value desert plant, a pioneer study on seed germination response to various agro-climatic factors was conducted at the Arid Zone Research Institute Bahawalpur. Healthy jojoba seeds were sown at the fortnightly intervals by dividing the whole year into 16 treatments to identify the optimum sowing time for the Cholistan desert of Bahawalpur. The results revealed that maximum germination rate of 85.63%, 85.93%, and 82.83% were found in treatment 16th September during the whole study period (2011-14). The 16th of March, 16thSeptember, and 1st August were the other suitable sowing times for jojoba as these showed 82.37%, 75.47%, and 71.57% of germination respectively.