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Genotype Specific SVR and NSVR Response of Hepatitis C to the Combined Interferon and Ribavirin Therapy

Genotype Specific SVR and NSVR Response of Hepatitis C to the Combined Interferon and Ribavirin Therapy

Muhammad Saqib Shahzad1, Amina Arif1,*,Saeeda Kalsoom2, Javed Iqbal3, Shahnam Shafique2, Muhammad Shahid Nadeem4 and Rafique Ahmed5

1Faculty of Life Sciences, University of the Central Punjab, Johar Town, Lahore 54000, Pakistan
2Institute of Molecular Biology and Biotechnology, University of Lahore, Lahore, Pakistan
3Department of Dentistry, Punjab Medical College, Faisalabad, Pakistan
4Department of Biochemistry, King Abdulaziz University, Jeddah 21589, Saudi Arabia
5Department of Surgery, Government Kot Khawaja Saeed Teaching Hospital, Lahore 54000, Pakistan

*      Corresponding author: draminaarif@gmail.com

 

Fig. 1.

A, the total number of enrolled patients and percentage of RVR and NRVR. B, the incidence of SVR and NSVR among the RVR and NRVR cases.

Fig. 2.

Incidence of SVR and NSVR among different age groups of patients.

Fig. 3.

The effect of HCV viral load on SVR. Patients were categorized according to viral load into four groups. In first group patient had viral load ≤ 200000, second group >200000 to 500000, third group >500000 to 800000 and fourth group with >800000 viral load.

Fig. 4.

The patients were divided into five groups on the basis of plasma ALT values and SVR for each group was determined.

Fig. 5.

The HCV genotypes were determined among all the investigated patients. The response to drug therapy was evaluated against all HCV genotypes. The results indicate a better response of drug therapy against genotype 3 as compared to the other genotypes.

Pakistan Journal of Zoology

August

Vol. 51, Iss. 4, Pages 1203-1598

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