Fungal Endophytes are Effective Alternatives and Novel Sources of Anticancer Drugs
Fungal Endophytes are Effective Alternatives and Novel Sources of Anticancer Drugs
Mohammad Ejaz1, Salma Javed2, Muhammad Hamza1, Sadia Tabassum2, Muhammad Abubakar3, Irfan Ullah4*
ABSTRACT
Natural bioactive molecules or compounds isolated from different living organisms are the rich sources for the novel drugs. Endophytes are the rich source of these bioactive molecules having a wide range of applications as compared to the original products. Fungal endophytes are the most commonly used endophytes for the isolation of various different types of bioactive molecules. These bioactive molecules can be used as antimicrobial, antibacterial and anticancer agents. Fungal endophytes like Taxomyces andreanae isolated from Yew plant have the potential to produce an anti-cancer compound called Paclitaxel. Other different fungal endophytic species produce various other types of anticancer compounds like camptothecin, podophyllotoxin, torreyanic acid, vincristine, and vinblastine. This review is organized to describe the general study of natural bioactive molecules or secondary metabolites secreted by fungal endophytes as novel sources of anticancer drugs. The main purpose of this review is to organize the effective compound of the fungal endophytes for cancer treatments.
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June 2020
Vol. 35, Iss. 1, pp. 1-165
