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Evaluation of Oxidative Status and Inflammatory Changes in Naturally Occurring Canine Visceral Leishmaniasis

Evaluation of Oxidative Status and Inflammatory Changes in Naturally Occurring Canine Visceral Leishmaniasis

Tünay Kontaş Aşkar1,*, Şinasi Aşkar1, Olga Büyükleblebici2 and Murat Güzel3

1Department of Nutrition and Dietetic, Faculty of Health Sciences, University of Karatekin, 18200, Çankırı, Turkey
2Department of Biochemistry, Faculty of Veterinary, University of Aksaray, Aksaray, Turkey
3Department of Internal Medicine, Faculty of Veterinary, University of Ondokuz Mayıs, Samsun, Turkey

*      Corresponding author: tunaykontas@yahoo.com

 

Fig. 1.

A, changes in MDA levels in dogs with VL and healthy controls. There is a significant increase in CVL group (P<0.001) when compared with the control group. MDA: malondialdehyde, CVL: canine visceral leishmaniasis; B, changes in antioxidant defense in dogs with VL and healthy controls. In CVL group, there is a significant reduce in TAC (P<0.05) and GSH (P<0,01) levels when compared with the control group. TAC, total antioxidant capacity; GSH, glutathione; CVL, canine visceral leishmaniasis.

Fig. 2.

 A, the correlation of MDA and TAC level in dogs with visceral leishmaniasis. Pearson’s rank correlation coefficient was r = -0.618, P<0.05; B, the correlation of MDA and GSH level in dogs with visceral leishmaniasis. Pearson’s rank correlation coefficient was r = -0.492, P<0.001.

Fig. 3.

A, the correlation of TNF-α and NO level in dogs with visceral leishmaniasis. Pearson’s rank correlation coefficient was r = 0.812, P<0.001; B, the correlation of TNF-α and MPO level in dogs with visceral leishmaniasis. Pearson’s rank correlation coefficient was r = 0.674, P<0.01; C, the correlation of TNF-α and ADA level in dogs with visceral leishmaniasis. Pearson’s rank correlation coefficient was r = 0.432, P<0.05.d); D, the correlation of TNF-α and IL-1β level in dogs with visceral leishmaniasis. Pearson’s rank correlation coefficient was r = 0.801, P<0.001.

Pakistan Journal of Zoology

August

Vol. 51, Iss. 4, Pages 1203-1598

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