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Evaluation of Oxidative Status and Inflammatory Changes in Naturally Occurring Canine Visceral Leishmaniasis

Evaluation of Oxidative Status and Inflammatory Changes in Naturally Occurring Canine Visceral Leishmaniasis

Tünay Kontaş Aşkar1,*, Şinasi Aşkar1, Olga Büyükleblebici2 and Murat Güzel3

1Department of Nutrition and Dietetic, Faculty of Health Sciences, University of Karatekin, 18200, Çankırı, Turkey
2Department of Biochemistry, Faculty of Veterinary, University of Aksaray, Aksaray, Turkey
3Department of Internal Medicine, Faculty of Veterinary, University of Ondokuz Mayıs, Samsun, Turkey

*      Corresponding author: tunaykontas@yahoo.com

 

ABSTRACT

The aim of the study is to determine the oxidative stress and inflammatory changes in naturally occurring canine visceral leishmaniasis (CVL). A total of 30 dogs, comprising 10 clinically healthy and 20 dogs with leishmaniasis were enrolled in this study. The diagnosis of canine visceral leishmaniasis was performed by the immune fluorescence antibody test with antibody titter ≥1:128 and lymph node smear examination. In blood samples of dogs with visceral leishmaniasis, levels of malondialdehyde, total antioxidant capacity, glutathione, nitric oxide, myeloperoxidase, adenosine deaminase and cytokines (TNF-alpha, IL-1β) were determined and compared with the healthy controls. Significantly high levels of plasma malondialdehyde, nitric oxide, myeloperoxidase, adenosine deaminase and cytokines and significantly low levels in total antioxidant capacity and glutathione levels were found in dogs with leishmaniasis when compared with the healthy controls. According to the result of this study, oxidative stress and inflammatory changes occur in CVL. And this is the first report for myeloperoxidase (MPO) activity in CVL. Therefore investigation of this enzyme activity in dogs with leishmaniasis may be used for the diagnosis and inflammatory changes in dogs with VL.
 

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Pakistan Journal of Zoology

August

Vol. 51, Iss. 4, Pages 1203-1598

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