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Evaluation of Cardioprotective Potential of Hydroalcoholic Leaf Extract of Citrullus colocynthis against Doxorubicin Induced Oxidative Stress in Rats

Evaluation of Cardioprotective Potential of Hydroalcoholic Leaf Extract of Citrullus colocynthis against Doxorubicin Induced Oxidative Stress in Rats

Ashira Manzoor1, Imran Ahmad Khan1,2*, Muqadas Sadiq3, Muhammad Omer Iqbal4 and Shaukat Hussain Munawar5

1Fatima-Tu-Zahra, Department of Life Sciences Muhammad Institute of Medical and Allied Sciences, Multan, Pakistan
2Department of Pharmacology, The Islamia University of Bahawalpur, Bahawalpur
3Ali-Ul-Murtaza, Department of Rehabilitation Sciences, Muhammad Institute of Medical and Allied Sciences, Multan, Pakistan
4Department of Shandong Provincial Key Laboratory of Glycoscience and Glycotechnology, Ocean University of China, China
5Department of Pharmacology and Toxicology, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan
 
* Corresponding author: imranahmadkhandurrani@gmail.com

Fig. 1.

Scavenging activity of leaf extract of C. colocynthis and Ascorbic acid on DPPH.

Fig. 2.

Effect of hydroalcoholic leaf extract of Citrullus colocynthis on level of oxidative stress in different markers in heart tissues. A, LDH; B, CK-MB; C, troponin-1; D, AST; E, ALT; F, ALP; G, CRP. ns (p > 0.05) did not show any significant reduction. *(p<0.05) showed significant reduction, **(p<0.001) showed highly significant reduction. 

Fig. 3.

(A) Effect of hydroalcoholic leaf extract on histological structure of rats. Heart section from DOX-induced group (B) shows images from heart sections of Extract 250mg/kg + DOX 18mg/kg (C) shows images from heart sections of extract 500 mg/kg + DOX 18mg/kg (D) Shows heart sections from Extract 750mg/kg + DOX 18mg/kg (E)shows images from heart sections of DZR 180mg/kg+ DOX 18mg/kg.

Pakistan Journal of Zoology

February

Vol. 55, Iss. 1, Pages 1-500

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